Forming runs, which frequently call for fewer specific cards than sets, are a good way to start the game. You're only one clist app downloadard away from finishing a run with a 4 or an 8 if you have a 5, 6, & 7 of hearts, for instance. Also, adaptability is essential when creating melds. Be willing to modify your plan of action in response to new cards that you draw during the game.
